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What are Transfer Factors? How they change your health

 Transfer Factors are small molecules that intelligently regulate immune system activities such as recognition, response and memory of foreign invaders. Transfer factors increase, decrease, and educates helper T Cells, Natural Killer (NK) cells, and Immunoglobulin Antibodies (IgA) according to your needs. They are found in the bodies of all higher animals. They are transferred from a mother who breast feeds to her new born infant to support the infant's immune system.

Dr. H. Sherwood Lawrence discovered he could transfer the successful immune response of a person who was exposed to a foreign invader by transferring the donor's dialyzable leukocytes to a naive recipient in the 1940s. He called this process the "transfer factor". Since then, researchers conducted thousands of transfer factor studies with mixed results depending on dosage, experimental design, and other factors. After 1992, Kirkpatrick distinguished specific transfer factors at the molecular level. His results indicate that transfer factors are constituted by a large group of amino acid molecules, of low molecular weights, from 1.0 to 6.0 kDa. Medline, the National Institute of Health’s online service published over 1,200 scientific abstracts on the immune benefits of transfer factors. An estimated $40,000,000 was spent on research. (See references)

During the early 1990s, David Lisonbee founder and president of 4Life Research discovered how pure transfer factor molecules can be extracted from colostrum and egg yolks and received patents for the processes. 4Life Research chose colostrum and egg yolks because they knew that cows and chickens are exposed to a broad spectrum of foreign invaders from being outdoors and eating off the ground. Cows and chickens also make transfer factors that are identical to transfer factors that healthy human immune systems develop if they are exposed to these potentially dangerous foreign invaders.

Currently, 4Life produces standardized health nutrition supplements that transfer this experienced immune system information to naive recipients so their immune systems are prepared to deal with these microscopic threats. Independent study results show that 4Life's transfer factors increase natural killer cell activities by 283 percent in pure form and 437 percent in their proprietary blend Transfer Factor Plus Tri-Factor Formula. This is more effective than any other method known at this time. (See chart) Transfer factors also increase immunoglobulin antibodies (IgA) by 73 percent.

The FDA generally regards transfer factors as safe. Pure transfer factors do not demonstrate toxicity even at 200 times the recommended dose. Transfer factors are a normal part of our bodies' so there are no drug interactions with pure transfer factors.

Independent comparison studies show other forms of extraction and immune system support products are relatively costly and ineffective. Most just boost immune system activity which can leave your immune system out of balance. As with many revolutionary breakthroughs that threaten convention, 4Life transfer factors are being met with sometimes criminal contempt (1).

While 4life transfer factor molecules speed up recognition of threats, modulate your immune system response, and remembers these invaders so your immune system is prepared if the threat returns, there is something more. Through thousands of studies and years of research, 4Life researchers found even smaller molecules. They call these nanofractions nanofactors. Nanofactors give your immune system the intuition to know when to act, how to act, and when to rest after it has the threat under control. Taking 4Life Transfer Factors with nanofractions effectively helps your immune system recognize and fight off threats or foreign invaders, and then preserves energy by reducing your immune system response when the threat is under control according to your individual needs. This restores your energy levels so you can do more of the things you want to do.

Another reason for using transfer factors comes from the increase in new antibiotic resistant bacteria, and the many adverse side effects of antibiotics. According to recent methodological studies from Russia, the natural immune system support provided by transfer factors offers so many benefits over antibiotics that they now recommend that their doctors use transfer factors before resorting to the use of antibiotics.

The daily need for 4Life Transfer Factors in children and adults comes from the interplay of genetic and environmental threats that weaken and/or over-activate healthy immune systems responses to foreign invaders. It is well known that pollution, poor eating habits, lack of exercise, and legal and illegal drugs, threaten our health and lifestyles. Transfer factor is one of those health nutrition supplements that can change the course of your life for the better.

1. Viza, D. (1996). AIDS and transfer factor: myths, certainties and realities. Biotherapy (Dordrecht, Netherlands), 9(1-3), 17-26. Persistent link to this record



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• Transfer Factor Goes To The Olympics

• Four of the most important steps you can take to improve your health

• Have Nutrition Supplements Cured Diseases?

• Do 4Life Research Nutrition Supplements Really Work?

• Is 4Life Transfer Factor Safe For Kids

• Health Nutrition Supplements and Drugs

• Dr. Duane Townsend, M.D. on 4Life Transfer Factor

• Abstracts About Transfer Factors I

• Abstracts About Transfer Factors II

• 4Life Transfer Factors increase Immunoglobulin Antibodies 73 Percent

• Learn About Compounds That Complement Transfer Factors

• Structural nature and functions of transfer factors - Kirkpatrick





Industry Authority Sites



• Natural Products Association

• American Herbal Products Association

• Council For Responsible Nutrition

References

Espinosa Padilla, S., Orozco, S., Plaza, A., Estrada Parra, S., Estrada García, I., Rosales González, M., et al. (2009). [Effect of transfer factor on treatment with glucocorticoids in a group of pediatric patients with persistent moderate allergic asthma]. Revista Alergia Mexico (Tecamachalco, Puebla, Mexico: 1993), 56(3), 67-71. Retrieved from MEDLINE database.

Dvoroznáková, E., Porubcová, J., & Sevcíková, Z. (2009). Immune response of mice with alveolar echinococcosis to therapy with transfer factor, alone and in combination with albendazole. Parasitology Research, 105(4), 1067-1076. Retrieved from MEDLINE database.

Grinevich, I., Fil'chakov, F., Shumilina, E., Lën, A., & Shved, V. (2009). [Transfer factor specific to mouse lung carcinoma of Lewis]. Voprosy Onkologii, 55(5), 612-618. Retrieved from MEDLINE database.

Berrón-Pérez, R., Chávez-Sánchez, R., Estrada-García, I., Espinosa-Padilla, S., Cortez-Gómez, R., Serrano-Miranda, E., et al. (2007). Indications, usage, and dosage of the transfer factor. Revista Alergia Mexico (Tecamachalco, Puebla, Mexico: 1993), 54(4), 134-139. Retrieved from MEDLINE database.

Flores Sandoval, G., Gómez Vera, J., Orea Solano, M., López Tiro, J., Serrano, E., Rodríguez, A., et al. (2005). [Transfer factor as specific immunomodulator in the treatment of moderate-severe atopic dermatitis]. Revista Alergia Mexico (Tecamachalco, Puebla, Mexico: 1993), 52(6), 215-220. Retrieved from MEDLINE database.

Leng, H., Liu, W., Zhu, Z., & Han, L. (2004). [Analysis of the contents of Zn, Cu, Fe, Mn, Co and Ni in thymopeptide and transfer factor biological injections]. Guang Pu Xue Yu Guang Pu Fen Xi = Guang Pu, 24(5), 625-627. Retrieved from MEDLINE database.

Orozco, T., Solano, M., Sandoval, G., Vera, J., & Parra, S. (2004). [Inflammatory mediators in patients with atopic dermatitis after treatment with transfer factor]. Revista Alergia Mexico (Tecamachalco, Puebla, Mexico: 1993), 51(4), 151-154. Retrieved from MEDLINE database.

García Angeles, J., Flores Sandoval, G., Orea Solano, M., Serrano, E., & Estrada Parra, S. (2003). [Lymphocyte apoptosis in atopic dermatitis treated with transfer factor]. Revista Alergia Mexico (Tecamachalco, Puebla, Mexico: 1993), 50(1), 3-7. Retrieved from MEDLINE database.

Kirkpatrick, C. (2000). Transfer factors: identification of conserved sequences in transfer factor molecules. Molecular Medicine (Cambridge, Mass.), 6(4), 332-341. Retrieved from MEDLINE database.

Dumonde, D., Kirkpatrick, C., & Pizza, G. (2000). Eleventh International Congress on Transfer Factors: March 1-4, 1999, Monterrey, Nuevo Leon, Mexico. Journal Of Interferon & Cytokine Research: The Official Journal Of The International Society For Interferon And Cytokine Research, 20(4), 439-441. Retrieved from MEDLINE database.

Holeva, O., Paster, I., Liubchenko, T., Paster, I., Kholodna, L., Zamotaierva, H., et al. (2000). [The immune reactivity transfer factor as a modulator of lymphocyte functional activity in rats]. Fiziolohichnyĭ Zhurnal (Kiev, Ukraine: 1994), 46(4), 58-65. Retrieved from MEDLINE database.

Cordero Miranda, M., Flores Sandoval, G., Orea Solano, M., Estrada Parra, S., & Serrano Miranda, E. (1999). [Safety and efficacy of treatment for severe atopic dermatitis with cyclosporin A and transfer factor]. Revista Alergia Mexico (Tecamachalco, Puebla, Mexico: 1993), 46(2), 49-57. Retrieved from MEDLINE database.

Chivinda Eduardo, A., & Kalynovs'ka, I. (2000). [Immunomorphological changes in the lymph nodes and spleen of rats sensitized with the transfer factor]. Fiziolohichnyĭ Zhurnal (Kiev, Ukraine: 1994), 46(4), 66-70. Retrieved from MEDLINE database.

Foschi, F., Marsigli, L., Bernardi, M., Salvi, F., Mascalchi, M., Gasbarrini, G., et al. (2000). Acute multifocal cerebral white matter lesions during transfer factor therapy. Journal Of Neurology, Neurosurgery, And Psychiatry, 68(1), 114-115. Retrieved from MEDLINE database.

Dwyer, J. (1996). Transfer factor in the age of molecular biology: a review. Biotherapy (Dordrecht, Netherlands), 9(1-3), 7-11. Retrieved from MEDLINE database. Note: Transfers secondary immunity across species.

Kirkpatrick, C. (1996). Activities and characteristics of transfer factors. Biotherapy (Dordrecht, Netherlands), 9(1-3), 13-16. Retrieved from MEDLINE database. Note: Oral bio-availability.

Dahlqvist, M., Lagerstrand, L., & Nilsen, A. (1994). Repeated measurements of transfer factor in rabbits: an animal model suitable for evaluation of short-term exposure. Clinical Physiology (Oxford, England), 14(1), 53-61. Retrieved from MEDLINE database.

Whyte, R., Schork, M., Sloan, H., Orringer, M., & Kirsh, M. (1992). Adjuvant treatment using transfer factor for bronchogenic carcinoma: long-term follow-up. The Annals Of Thoracic Surgery, 53(3), 391-396. Retrieved from MEDLINE database.

Rozzo, S., Merryman, C., & Kirkpatrick, C. (1988). Murine transfer factor. IV. Studies with genetically regulated immune responses. Cellular Immunology, 115(1), 130-145. Retrieved from MEDLINE database.

Kirkpatrick, C. (1988). Transfer factor. The Journal Of Allergy And Clinical Immunology, 81(5 Pt 1), 803-813. Retrieved from MEDLINE database.

Spitler, L., & Miller, L. (1987). Clinical trials of transfer factor in malignancy. Journal Of Experimental Pathology, 3(4), 549-564. Retrieved from MEDLINE database.

Carey, J., Lederman, M., Toossi, Z., Edmonds, K., Hodder, S., Calabrese, L., et al. (1987). Augmentation of skin test reactivity and lymphocyte blastogenesis in patients with AIDS treated with transfer factor. JAMA: The Journal Of The American Medical Association, 257(5), 651-655. Retrieved from MEDLINE database.

Louie, E., Borkowsky, W., Klesius, P., Haynes, T., Gordon, S., Bonk, S., et al. (1987). Treatment of cryptosporidiosis with oral bovine transfer factor. Clinical Immunology And Immunopathology, 44(3), 329-334. Retrieved from MEDLINE database.

Kirkpatrick, C., Rozzo, S., & Mascali, J. (1985). Murine transfer factor. III. Specific interactions between transfer factor and antigen. Journal Of Immunology (Baltimore, Md.: 1950), 135(6), 4027-4033. Retrieved from MEDLINE database.

Schütt, C., Eggers, G., Schröder, I., Kruse, H., Schulz, M., & Blau, H. (1983). [Discrepancy between the clinical and immunologic picture of in vitro diagnosis during transfer factor therapy in a patient with Wiscott-Aldrich syndrome]. Folia Haematologica (Leipzig, Germany: 1928), 110(5), 677-684. Retrieved from MEDLINE database.

Steele, R., Myers, M., & Vincent, M. (1980). Transfer factor for the prevention of varicella-zoster infection in childhood leukemia. The New England Journal Of Medicine, 303(7), 355-359. Retrieved from MEDLINE database.

Spitler, L. (1979). Transfer factor in immunodeficiency diseases. Annals Of The New York Academy Of Sciences, 332228-235. Retrieved from MEDLINE database.

Timár, L., Budai, J., Nyerges, G., Szigeti, R., Hollós, I., & Sonkoly, I. (1978). Progressive vaccinia: immunological aspects and transfer factor therapy. Infection, 6(4), 149-153. Retrieved from MEDLINE database.

Likholetov, S., Prokof'eva, E., & Rogozhkina, N. (1978). [Transfer of cellular immunity to the causative agent of coccidioidosis using the transfer factor in mice]. Zhurnal Mikrobiologii, Epidemiologii, I Immunobiologii, (9), 60-64. Retrieved from MEDLINE database.

Rifkind, D., Frey, J., Petersen, E., & Dinowitz, M. (1977). Transfer of delayed hypersensitivity in mice to microbial antigens with dialyzable transfer factor. Infection And Immunity, 16(1), 258-262. Retrieved from MEDLINE database.

Businco, L., Aiuti, F., Franchi, F., Frati, C., Cavalieri, R., & Rezza, E. (1976). Clinical and immunological improvement in a patient with chronic mucocutaneous candidiasis treated with transfer factor. Allergologia Et Immunopathologia, 4(5), 345-350. Retrieved from MEDLINE database.

Dunnick, W., & Bach, F. (1975). Guinea pig transfer factor-like activity detected in vitro. Proceedings Of The National Academy Of Sciences Of The United States Of America, 72(11), 4573-4576. Retrieved from MEDLINE database.

Kirkpatrick, C. (1975). Restoration of cell-mediated immune responses with transfer factor. Birth Defects Original Article Series, 11(1), 441-444. Retrieved from MEDLINE database.

Kirkpatrick, C. (1975). Properties and activities of transfer factor. The Journal Of Allergy And Clinical Immunology, 55(6), 411-421. Retrieved from MEDLINE database.

Käckell, Y., Grob, P., Kreth, W., Kibler, R., & Meulen, V. (1975). Transfer factor therapy in patients with subacute sclerosing panencephalitis. Journal Of Neurology, 211(1), 39-49. Retrieved from MEDLINE database.

Levin, A., Byers, V., Fudenberg, H., Wybran, J., Hackett, A., Johnston, J., et al. (1975). Osteogenic sarcoma. Immunologic parameters before and during immunotherapy with tumor-specific transfer factor. The Journal Of Clinical Investigation, 55(3), 487-499. Retrieved from MEDLINE database.

Khan, A., Hill, J., MacLellan, A., Loeb, E., Hill, N., & Thaxton, S. (1975). Improvement in delayed hypersensitivity in Hodgkin's disease with transfer factor: lymphapheresis and cellular immune reactions or normal donors. Cancer, 36(1), 86-89. Retrieved from MEDLINE database.

Rocklin, R. (1975). Use of transfer factor in patients with depressed cellular immunity and chronic infection. Birth Defects Original Article Series, 11(1), 431-435. Retrieved from MEDLINE database.

Zuckerman, K., Neidhart, J., Balcerzak, S., & LoBuglio, A. (1974). Immunologic specificity of transfer factor. The Journal Of Clinical Investigation, 54(4), 997-1000. Retrieved from MEDLINE database.

Spitler, L., Levin, A., Stites, D., Fudenberg, H., Pirofsky, B., August, C., et al. (1972). The Wiskott-Aldrich syndrome. Results of transfer factor therapy. The Journal Of Clinical Investigation, 51(12), 3216-3224. Retrieved from MEDLINE database.

Kirkpatrick, C., Rich, R., & Smith, T. (1972). Effect of transfer factor on lymphocyte function in anergic patients. The Journal Of Clinical Investigation, 51(11), 2948-2958. Retrieved from MEDLINE database.

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